解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::N-ethylmaleimide sensitive factor (NSF) is a key protein of intracellular membrane traffic. NSF is a highly conserved protein belonging to the ATPases associated with other activities (AAA+ proteins). AAA+ share common domains and all transduce ATP hydrolysis into major conformational movements that are used to carry ...
journal_title:Biopolymers
pub_type: 杂志文章,评审
doi:10.1002/bip.22854
更新日期:2016-08-01 00:00:00
abstract::We have extended our studies of Trp/Trp to other Aryl/Aryl through-space interactions that stabilize hairpins and other small polypeptide folds. Herein we detail the NMR and CD spectroscopic features of these types of interactions. NMR data remains the best diagnostic for characterizing the common T-shape orientation....
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22821
更新日期:2016-06-01 00:00:00
abstract::Constrained azapeptides were designed based on the Ala-Val-Pro-Ile sequence from the second mitochondria-derived activator of caspases (Smac) protein and tested for ability to induce apoptosis in cancer cells. Diels-Alder cyclizations and Alder-ene reactions on azopeptides enabled construction of a set of constrained ...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22851
更新日期:2016-05-01 00:00:00
abstract::Cyclic tri-β-peptide having tetrathiafulvalene (TTF) at the side chain was synthesized to prepare a peptide nanotube aligning TTF side chains along the nanotube. The polarized light microscopic observations revealed crystallization of the cyclic peptide by the vapor diffusion method. Fourier-transform infrared and ele...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22850
更新日期:2016-05-01 00:00:00
abstract::Dehydrophenylalanine, ΔPhe, is the most commonly studied α,β-dehydroamino acid. In nature, further modifications of the α,β-dehydroamino acids were found, for example, replacement of the C-terminal amide group by oxazole ring. The conformational properties of oxazole-dehydrophenylalanine residue (ΔPhe-Ozl), both isome...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22852
更新日期:2016-05-01 00:00:00
abstract::Hemochromatosis factor E (HFE) is a member of class I MHC family and plays a significant role in the iron homeostasis. Denaturation of HFE induced by guanidinium chloride (GdmCl) was measured by monitoring changes in [θ]222 (mean residue ellipticity at 222 nm), intrinsic fluorescence emission intensity at 346 nm (F346...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22760
更新日期:2016-03-01 00:00:00
abstract::We have utilized a de novo designed two-stranded α-helical coiled-coil template to display conserved α-helical epitopes from the stem region of hemagglutinin (HA) glycoproteins of influenza A. The immunogens have all the surface-exposed residues of the native α-helix in the native HA protein of interest displayed on t...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22808
更新日期:2016-03-01 00:00:00
abstract::The abnormal aggregation of amyloid proteins is reported to play a critical role in the etiology of neurodegenerative disorders. Studies have shown that excessive ferric irons are associated with the misfolding of amyloid proteins, and that (-)-epigallocatechin gallate (EGCG) is a good metallic ion chelator with inhib...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22752
更新日期:2016-02-01 00:00:00
abstract::RADA-16-I is a self-assembling peptide which forms biocompatible fibrils and hydrogels. We used molecular dynamics simulations, atomic-force microscopy, NMR spectroscopy, and thioflavin T binding assay to examine size, structure, and morphology of RADA-16-I aggregates. We used the native form of RADA-16-I (H-(ArgAlaAs...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22755
更新日期:2016-01-01 00:00:00
abstract::Peptides are frequently used model systems for protein folding. They are also gaining increased importance as therapeutics. Here, the ability of molecular dynamics (MD) simulation for describing the structure and dynamics of β-hairpin peptides was investigated, with special attention given to the impact of a single in...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22671
更新日期:2015-11-01 00:00:00
abstract::The IgY antibodies offer an attractive alternative to mammalian IgGs in research, diagnosis and medicine. The isolation of immunoglobulin Y from the egg yolks is efficient and economical, causing minimal suffering to animals. Here we present the methodology for the production of IgY antibodies specific to Staphylococc...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22695
更新日期:2015-09-01 00:00:00
abstract::The creation of peptide libraries by site-selective modification of a few peptide substrates would increase the efficiency of discovery processes, but still is a real synthetic challenge. The site-selective modification of small peptides at serine or threonine residues, by using a short scission-addition procedure, al...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22642
更新日期:2015-09-01 00:00:00
abstract::The magnitude and nature of lesion-induced energetic perturbations empirically correlate with mutagenicity/cytotoxicity profiles and can be predictive of lesion outcomes during polymerase-mediated replication in vitro. In this study, we assess the sequence and counterbase-dependent energetic impact of the Thymine glyc...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22680
更新日期:2015-09-01 00:00:00
abstract::This brief account traces the development of a "competition dialysis" method used to characterize the structural and sequence selectivity of DNA binding compounds. The method was inspired by a simple "differential dialysis" method pioneered by Don Crothers to explore base-selective intercalator binding. Results from c...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22660
更新日期:2015-09-01 00:00:00
abstract::The design of biomimetic materials through molecular self-assembly is a growing area of modern nanotechnology. With problems of protein folding, self-assembly, and sequence-structure relationships as essential in nanotechnology as in biology, the effect of the nucleation of β-hairpin formation by proline on the foldin...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22622
更新日期:2015-06-01 00:00:00
abstract::Nucleolar targeting peptides (NrTPs) are a family of cell penetrating peptides (CPPs) derived from crotamine, a rattlesnake venom toxin. They were named NrTPs for their remarkable nucleolus-homing properties and have been studied for their potential as drug delivery vehicles. Live cell microscopy experiments were cond...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22610
更新日期:2015-03-01 00:00:00
abstract::Disintegrins, small molecular weight proteins contained in the venom of vipers and rattlesnakes, are high-affinity and selectivity integrin antagonists. Disintegrins inhibitory epitope mainly consists in a tripeptide sequence localized in a mobile loop protruding from the protein core. RTS and/or KTS tripeptide charac...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22578
更新日期:2015-03-01 00:00:00
abstract::Amidated kyotorphin (L-Tyr-L-Arg-NH2; KTP-NH2) causes analgesia when systemically administered. The lipophilic ibuprofen-conjugated derivative of KTP-NH2 has improved analgesic efficacy. However, fast degradation by peptidases impacts negatively in the pharmacodynamics of these drugs. In this work, selected derivative...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22580
更新日期:2015-01-01 00:00:00
abstract::The preferred helical screw senses of chiral α-amino acids with a C(α)-tetrasubstituted α-carbon atom, as determined in the crystal state by X-ray diffraction analyses on derivatives and peptides, are reviewed. This survey covers C(α)-methylated and C(α)-ethylated α-amino acids, as well as α-amino acids cyclized on th...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22581
更新日期:2015-01-01 00:00:00
abstract::Tissue engineering techniques particularly using electrospun scaffolds have been intensively used in recent years for the development of small diameter vascular grafts. However, the development of a completely successful scaffold that fulfills multiple requirements to guarantee complete vascular regeneration remains c...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22524
更新日期:2014-12-01 00:00:00
abstract::The characterization of elastic properties of biopolymers is crucial to understand many molecular reactions determined by conformational bending fluctuations of the polymer. Direct measurement of such elastic properties using single-molecule methods is usually hindered by the intrinsic tendency of such biopolymers to ...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22533
更新日期:2014-12-01 00:00:00
abstract::Peptomers are oligomeric molecules composed of both α-amino acids and N-substituted glycine monomers, thus creating a hybrid of peptide and peptoid units. Peptomers have been used in several applications such as antimicrobials, protease inhibitors, and antibody mimics. Despite the considerable promise of peptomers as ...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22516
更新日期:2014-09-01 00:00:00
abstract::This work theoretically investigates the mechanical properties of a novel silk-derived biopolymer as polymerized in silico from sericin and elastin-like monomers. Molecular Dynamics simulations and Steered Molecular Dynamics were the principal computational methods used, the latter of which applies an external force o...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22494
更新日期:2014-09-01 00:00:00
abstract::Collagen is a natural protein, which is used as a vital biomaterial in tissue engineering. The major concern about native collagen is lack of its thermal stability and weak resistance to proteolytic degradation. In this scenario, the crosslinking compounds used for stabilization of collagen are mostly of chemical natu...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22473
更新日期:2014-08-01 00:00:00
abstract::The ion atmosphere created by monovalent (Na(+) ) or divalent (Mg(2+) ) cations surrounding a B-form DNA duplex were examined using atomistic molecular dynamics (MD) simulations and the nonlinear Poisson-Boltzmann (PB) equation. The ion distributions predicted by the two methods were compared using plots of radial and...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22461
更新日期:2014-08-01 00:00:00
abstract::The maltose transporter from Escherichia coli is one of the ATP-binding cassette (ABC) transporters that utilize the energy from ATP hydrolysis to translocate substrates across cellular membranes. Until 2011, three crystal structures have been determined for maltose transporter at different states in the process of tr...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22455
更新日期:2014-07-01 00:00:00
abstract::The conformational preferences of blocked alanine dipeptide (ADP), Ac-Ala-NHMe, in aqueous solution were studied using vibrational circular dichroism (VCD) together with density functional theory (DFT) calculations. DFT calculations of three most representative conformations of ADP surrounded by six explicit water mol...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22460
更新日期:2014-07-01 00:00:00
abstract::Although several models have been proposed for the interaction of collagen with gelatinase-A (matrix metalloproteinases-2 (MMP-2)), the extensive role of each domain of gelatinase A in hydrolyzing the collagens with and without interruptions is still elusive. Molecular docking, molecular dynamics (MD) simulation, norm...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22457
更新日期:2014-07-01 00:00:00
abstract::Apelin is the endogenous ligand of APJ, which belongs to the superfamily of G protein-coupled receptors. In recent years, the apelin/APJ system has been detected in many tissues and emerges as a promising target for the treatment of various pathophysiological conditions. Pyr1-apelin-13 is the major isoform of apelin i...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22498
更新日期:2014-07-01 00:00:00
abstract::For mimicking macromolecular crowding of DNA quadruplexes, various crowding agents have been used, typically PEG, with quadruplexes of micromolar strand concentrations. Thermal and thermodynamic stabilities of these quadruplexes increased with the concentration of the agents, the rise depended on the crowder used. A d...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22400
更新日期:2014-04-01 00:00:00
abstract::The rheological characteristics of gastric and duodenal mucin solutions, the building blocks of the mucus layer that covers the epithelia of the two organs, were investigated using particle tracking microrheology. We used biochemically well characterized purified porcine mucins (MUC5AC and MUC2) as models for human mu...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22372
更新日期:2014-04-01 00:00:00
abstract::Hyaluronic acid (HA) is an important biomacromolecule, which fulfils a number of vital physiological functions (especially in the joint synovial fluid) and also has consumer and pharmaceutical applications. HA solution properties have already been quite thoroughly characterized in response to steady shear flows but ar...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22357
更新日期:2014-03-01 00:00:00
abstract::A novel heptapeptide comprising Ile-Gln-Ser-Pro-His-Phe-Phe (IQSPHFF) identified and found to undergo self-assembly into microparticles in solution. To understand the effects of ultraviolet (UV) irradiation on the self-assembly process, IQSPHFF solutions were exposed to the UV light of 365 nm at room temperature. This...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22346
更新日期:2014-03-01 00:00:00
abstract::The enhanced nucleophilicity and redox sensitivity of the thiol group renders cysteine residues susceptible to numerous electrophilic and oxidative post-translational modifications to form disulfides, sulfenic acids, nitrosothiols, and lipid-modified species. Outside of these well-characterized modifications of cystei...
journal_title:Biopolymers
pub_type: 杂志文章,评审
doi:10.1002/bip.22252
更新日期:2014-02-01 00:00:00
abstract::Ubiquitin (Ub) is a small 76 amino acid long protein that is highly conserved in all eukaryotes studied to date. In humans, more than 600 ligases are involved in the reversible modification of specific lysine side-chain amines in substrate proteins by conjugation with the C-terminal carboxylate of Ub. Initially monoub...
journal_title:Biopolymers
pub_type: 杂志文章,评审
doi:10.1002/bip.22253
更新日期:2014-02-01 00:00:00
abstract::G protein-coupled receptor kinase 2 (GRK2) plays a central role in the cellular transduction network. In particular, during chronic heart failure GRK2 is upregulated and believed to contribute to disease progression. Thereby, its inhibition offers a potential therapeutic solution to several pathological conditions. In...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22295
更新日期:2014-01-01 00:00:00
abstract::Sequence-specific optical signals are used to establish long-range sequence order and identification for fragments hundreds of kilo bases in length. ...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22332
更新日期:2013-12-01 00:00:00
abstract::Laminins are a multifunctional molecule with numerous active sites that have been identified in short peptide sequences. Mixed peptide-conjugated chitosan membranes using laminin-derived active peptides have been previously demonstrated to be useful as a biomaterial for tissue engineering. In this study, two syndecan-...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22303
更新日期:2013-11-01 00:00:00
abstract::This work advances bottom-up design of bioinspired materials built from peptide-amphiphiles, which are a class of bioconjugates in which a biofunctional peptide is covalently attached to a hydrophobic moiety that drives self-assembly in aqueous solution. Specifically, this work highlights the importance of peptide con...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22217
更新日期:2013-09-01 00:00:00
abstract::Additive physical properties of DNA double strand polymers have been expanded in terms of 8 irreducible parameters. This provided consistency relations among the corresponding 10 duplex dimer contributions. To allow for oligomer analysis, end parameters were often added, and this would add extra degrees of freedom to ...
journal_title:Biopolymers
pub_type: 杂志文章
doi:10.1002/bip.22214
更新日期:2013-08-01 00:00:00